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Search for "near-infrared fluorescence probes" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.

Amyloid-β probes: Review of structure–activity and brain-kinetics relationships

Todd J. Eckroat,
Abdelrahman S. Mayhoub and
Sylvie Garneau-Tsodikova

Beilstein J. Org. Chem. 2013, 9, 1012–1044, doi:10.3762/bjoc.9.116

relationships with regards to affinity for target and brain kinetics. Several probes discussed herein show particularly promising results and will be of immense value moving forward in the fight against AD. Keywords: Alzheimer’s disease; in vivo detection; near-infrared fluorescence probes; PET/SPECT imaging

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Graphical Abstract

Figure 1: Structures of A. dyes originally used to stain Aβ and B. newer scaffolds explored for the developme...

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Scheme 1: General synthetic strategies (Gs) used to introduce A. ¹⁸F, B. ¹¹C, C. ^99mTc/Re, and D. ¹²³I and ¹²⁵...

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Scheme 2: A. Structures of radiolabeled chalcone analogues discussed. B.–D. Synthetic schemes for the prepara...

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Scheme 3: A. Structures of the radiolabeled flavone and aurone analogues discussed. B. Synthetic scheme for t...

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Scheme 4: A. Structures of the radiolabeled stilbene analogues discussed. B. Synthetic scheme for the prepara...

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Scheme 5: A. Structures of the diphenyl-1,3,4- and diphenyl-1,2,4-oxadiazoles discussed. B.,C. Synthetic sche...

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Figure 2: Structures of the radiolabeled benzothiazole analogues discussed.

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Scheme 6: A.–F. Synthetic schemes for the preparation of [¹¹C]56b, [¹¹C]56c, 57, 58a,b, 61, and [¹⁸F]65a–d.

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Scheme 7: A. Structures of the [Re]- and [^99mTc]-labeled benzothiazole analogues discussed. B.,C. Synthetic s...

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Figure 3: Structures of the radiolabeled benzoxazole analogues discussed.

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Scheme 8: A.–E. Synthetic schemes for the preparation of 94, [¹²³I]95e, 96–98.

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Figure 4: Structures of the radiolabeled benzofuran analogues discussed.

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Scheme 9: A.–E. Synthetic schemes for the preparation of 121, [¹²⁵I]122a, 123a,b, 125a,b, and 126.

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Scheme 10: A. Structures of the radiolabeled imidazopyridine analogues discussed. B. Synthetic scheme for the ...

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Scheme 11: Synthetic scheme for the preparation of the benzimidazole 146.

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Figure 5: Structures of the quinolines discussed.

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Scheme 12: Synthetic scheme for the preparation of the naphthalene analogues 152 and 160a,b.

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Scheme 13: A. Structures of the radiolabeled analogues resulting from the combination of various scaffolds. B.,...

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Scheme 14: A.–C. Synthetic schemes for the preparation of radiolabeled probes with unique scaffolds.

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Scheme 15: A. Structures of the oxazine-derived fluorescence probes discussed. B. Synthetic scheme for the pre...

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Figure 6: Structure of THK-265 (190).

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Scheme 16: Synthetic scheme for the preparation of quinoxaline analogue 191.

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Review

Published 28 May 2013

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